{"id":274,"date":"2023-08-09T17:30:21","date_gmt":"2023-08-09T09:30:21","guid":{"rendered":"https:\/\/mrc.som.nycu.edu.tw\/?page_id=274"},"modified":"2026-05-14T14:09:27","modified_gmt":"2026-05-14T06:09:27","slug":"%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c-2","status":"publish","type":"page","link":"https:\/\/mrc.som.nycu.edu.tw\/eng\/%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c-2\/","title":{"rendered":"RESEARCH RESULTS"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u7814\u7a76\u91cd\u9ede<\/strong><\/p>\n<cite><strong><p>\u7814\u7a76\u5fae\u83cc\u53e2\u5c0d\u65bc\u6d88\u5316\u7cfb\u764c\u75c7\u3001\u4ee3\u8b1d\u75c7\u5019\u7fa4\u3001\u7f55\u898b\u4ee3\u8b1d\u7570\u5e38\u75be\u75c5\u4e4b\u89d2\u8272\uff0c\u4ee5\u53ca\u5176\u81f4\u75c5\u6a5f\u8f49\uff0c\u4e26\u767c\u5c55\u4ee5\u5fae\u83cc\u53e2\u70ba\u6838\u5fc3\u7684\u751f\u7269\u6a19\u8a18\u53ca\u4ecb\u5165\u7b56\u7565\u3002<br>\u4ee5\u5fae\u83cc\u53e2\u70ba\u6838\u5fc3\uff0c\u7814\u7a76\u4e0a\u8ff0\u75be\u75c5\u53ca\u5176\u4e9e\u5065\u5eb7\u65cf\u7fa4\u4e4b\u591a\u9ad4\u5b78\u53ca\u8868\u578b\u7d44\u5b78\uff0c\u4e26\u5efa\u7acb\u5176\u6578\u4f4d\u5206\u8eab\uff0c\u4ee5\u9032\u884c\u75be\u75c5\u7684\u9810\u6e2c\u53ca\u9810\u9632\u3002<br>\u4ee5\u4e0a\u8ff0\u7814\u7a76\u4f86\u767c\u5c55\u7cbe\u6e96\u5065\u5eb7\u7684\u7522\u3001\u5b78\u3001\u7814\u4e4b\u7814\u767c\u751f\u614b\u93c8\uff0c\u62d3\u5c55\u5f9e\u57fa\u790e\u5230\u81e8\u5e8a\u3001\u5be6\u9a57\u5ba4\u5230\u75c5\u623f\u7167\u8b77\u3001\u91ab\u9662\u5230\u793e\u5340\u7684\u7522\u5b78\u5275\u65b0\u7814\u767c\u50f9\u503c\u3002<\/p><\/strong><\/cite><\/blockquote>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u8fd1\u671f\u8ad6\u6587\u767c\u8868<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<figure class=\"wp-block-table alignwide\"><table class=\"has-fixed-layout\"><thead><tr><th><strong>\u767c\u8868\u65e5\u671f<\/strong><\/th><th><strong>\u4f5c\u8005<\/strong><\/th><th><strong>\u8ad6\u6587\u540d\u7a31<\/strong><\/th><th><strong>\u6458\u8981<\/strong><\/th><th><strong>\u671f\u520a\u540d\u7a31<\/strong><\/th><th><strong>SCI Impact Factor<\/strong><\/th><\/tr><\/thead><tbody><tr><td>2026\u5e744\u670817\u65e5<\/td><td>\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/www.mdpi.com\/2079-6374\/16\/4\/223\">Rapid electrochemical profiling of fecal short chain acids using esterification\/dissociation fingerprints and artificial neural networks<\/a><\/td><td>\u672c\u7814\u7a76\u958b\u767c\u4e86\u4e00\u7a2e\u5feb\u901f\u53c8\u4fbf\u5b9c\u7684\u65b9\u6cd5\uff0c\u53ef\u4ee5\u6aa2\u6e2c\u4eba\u9ad4\u7cde\u4fbf\u4e2d\u7684\u77ed\u93c8\u8102\u80aa\u9178\uff08SCFAs\uff09\uff0c\u4e26\u7d50\u5408\u4eba\u5de5\u667a\u6167\u63d0\u9ad8\u5206\u6790\u6e96\u78ba\u5ea6\u3002\u7814\u7a76\u767c\u73fe\uff0c\u9019\u5957\u65b9\u6cd5\u5373\u4f7f\u9762\u5c0d\u8907\u96dc\u7684\u7cde\u4fbf\u6a23\u672c\uff0c\u4e5f\u80fd\u6e96\u78ba\u6e2c\u91cf\u4e19\u9178\u3001\u4e01\u9178\u7b49\u91cd\u8981\u4ee3\u8b1d\u7269\uff0c\u7d50\u679c\u8207\u50b3\u7d71 GC\u2013MS \u6aa2\u6e2c\u5e7e\u4e4e\u4e00\u81f4\u3002\u7531\u65bc\u6aa2\u6e2c\u901f\u5ea6\u5feb\u3001\u8a2d\u5099\u6210\u672c\u8f03\u4f4e\uff0c\u672a\u4f86\u6709\u6a5f\u6703\u61c9\u7528\u65bc\u5927\u91cf\u5065\u5eb7\u7be9\u6aa2\u8207\u9577\u671f\u8178\u9053\u5065\u5eb7\u76e3\u6e2c\u3002<\/td><td>Biosensors<\/td><td>5.6<\/td><\/tr><tr><td>2026\u5e744\u67086\u65e5<\/td><td>\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/dth\/2661014\">Objective and subjective assessments of the response of photobiomodulation therapy against alopecia areata<\/a><\/td><td>\u5149\u751f\u7269\u8abf\u7bc0\u6cbb\u7642\uff08PBMT\uff09\u53ef\u80fd\u662f\u4e00\u7a2e\u5177\u6f5b\u529b\u7684\u975e\u4fb5\u5165\u6027\u6cbb\u7642\u65b9\u5f0f\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u5713\u79bf\uff08AA\uff09\uff0c\u4e14\u4e0d\u6703\u7522\u751f\u5168\u8eab\u6027\u6216\u5c40\u90e8\u526f\u4f5c\u7528\u3002<\/td><td>Derm Ther<\/td><td>3.4<\/td><\/tr><tr><td>2026\u5e743\u670824\u65e5<\/td><td>\u5433\u8389\u73b2\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41877243\/\">Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress<\/a><\/td><td>\u9019\u4e9b\u7d50\u679c\u652f\u6301Nfil3\u4f5c\u70ba\u4e00\u500b\u95dc\u9375\u8abf\u63a7\u7bc0\u9ede\uff0c\u9023\u7d50\u8178\u9053\u83cc\u76f8\u529f\u80fd\u6f5b\u529b\u8207\u4ee3\u8b1d\u76f8\u95dc\u8102\u80aa\u6027\u809d\u75c5\uff08MASLD\uff09\u4e2d\u7684\u514d\u75ab\u8207\u4ee3\u8b1d\u53cd\u61c9\u3002\u5118\u7ba1\u76ee\u524d\u4ecd\u5c6c\u524d\u81e8\u5e8a\u7814\u7a76\uff0c\u672c\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u500b\u6a5f\u5236\u6027\u67b6\u69cb\uff0c\u8aaa\u660e\u8178\u9053\u5fae\u751f\u7269\u76f8\u95dc\u7684\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u5982\u4f55\u5f71\u97ff\u5bbf\u4e3b\u7684\u514d\u75ab\u8207\u4ee3\u8b1d\u6046\u5b9a\u3002\u672a\u4f86\u4ecd\u9700\u7d50\u5408\u665d\u591c\u7bc0\u5f8b\u8207\u4ee3\u8b1d\u7269\u5c64\u7d1a\u7684\u7814\u7a76\uff0c\u4ee5\u53ca\u4eba\u9ad4\u4ecb\u5165\u8a66\u9a57\u9a57\u8b49\uff0c\u4ee5\u91d0\u6e05\u83cc\u76f8\u2013Nfil3\u8ef8\u5728\u81e8\u5e8a\u4e0a\u7684\u5be6\u969b\u610f\u7fa9\u3002<\/td><td>J Transl Med<\/td><td>7.5<\/td><\/tr><tr><td>2026\u5e743\u670818\u65e5<\/td><td>\u5f35\u5a77\u5a77\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41862053\/\">CCL7 suppression alleviates vascular injury by blocking the CCR5\/STAT1 signaling pathway in chronic kidney disease<\/a><\/td><td>\u672c\u7814\u7a76\u63a2\u8a0e\u6162\u6027\u814e\u81df\u75c5\u4e2d\uff0c\u767c\u708e\u8da8\u5316\u56e0\u5b50CCL7\u5728\u5468\u908a\u52d5\u8108\u75be\u75c5\u767c\u5c55\u4e2d\u7684\u89d2\u8272\uff0c\u767c\u73feCKD\u5c0f\u9f20\u8840\u4e2dCCL7\u6fc3\u5ea6\u4e0a\u5347\uff0c\u4e26\u4f34\u96a8\u7f3a\u8840\u80a2\u9ad4\u8840\u6d41\u4e0b\u964d\u8207\u50b7\u53e3\u7652\u5408\u5ef6\u9072\u3002\u6291\u5236\u6216\u5254\u9664CCL7\u53ef\u4fc3\u9032\u65b0\u751f\u8840\u7ba1\u751f\u6210\u3001\u589e\u52a0\u6bdb\u7d30\u8840\u7ba1\u5bc6\u5ea6\u4e26\u6539\u5584\u8840\u6d41\u8207\u7d44\u7e54\u4fee\u5fa9\uff0c\u986f\u793a\u5176\u5c0d\u8840\u7ba1\u518d\u751f\u5177\u6709\u8ca0\u5411\u8abf\u63a7\u4f5c\u7528\u3002\u9032\u4e00\u6b65\u6a5f\u5236\u7814\u7a76\u6307\u51fa\uff0cCCL7\u900f\u904e\u8abf\u63a7CCR5\/STAT\u8a0a\u865f\u9014\u5f91\u5f71\u97ff\u5167\u76ae\u7d30\u80de\u529f\u80fd\uff0c\u56e0\u6b64\u53ef\u80fd\u6210\u70baCKD\u76f8\u95dc\u8840\u7ba1\u4f75\u767c\u75c7\u7684\u91cd\u8981\u6cbb\u7642\u6a19\u9776\u3002<\/td><td>Life Sciences<\/td><td>5.1<\/td><\/tr><tr><td>2026\u5e743\u670817\u65e5<\/td><td>\u694a\u6bc5\u8f1d\u8207\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41842890\/\">Assessing Major Adverse Liver Outcomes With Baclofen Compared to Acamprosate in Compensated Alcohol-Associated Cirrhosis<\/a><\/td><td>\u5728\u9019\u9805\u5927\u578b\u771f\u5be6\u4e16\u754c\u7814\u7a76\u4e2d\uff0c\u65bc\u4ee3\u511f\u671f\u9152\u7cbe\u76f8\u95dc\u809d\u786c\u5316\u60a3\u8005\u4e2d\uff0c\u4f7f\u7528Baclofen\u76f8\u8f03\u65bcAcamprosate\uff0c\u8207\u8f03\u9ad8\u7684\u809d\u6027\u8166\u75c5\u8b8a\u98a8\u96aa\u76f8\u95dc\u3002<\/td><td>Aliment Pharmacol Ther<\/td><td>6.7<\/td><\/tr><tr><td>2026\u5e743\u670814\u65e5<\/td><td>\u6797\u9a30\u7acb\u540c\u5b78\u8207\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41830903\/\">Real-World Safety of JAK Inhibitors in Skin Immune-Mediated Inflammatory Diseases: Boxed Warning Outcomes from a Multinational Cohort Study<\/a><\/td><td>\u6574\u9ad4\u7d50\u679c\u986f\u793a\uff0c\u5c0d\u65bc\u514d\u75ab\u4ecb\u5c0e\u767c\u708e\u6027\u75be\u75c5\uff08IMIDs\uff09\u60a3\u8005\uff0cJAKis\u5728\u5b89\u5168\u6027\u65b9\u9762\u53ef\u8207\u50b3\u7d71\u6cbb\u7642\u76f8\u6bd4\uff0c\u672a\u5448\u73fe\u8f03\u9ad8\u98a8\u96aa\u3002<\/td><td>Clin Pharmacol Ther<\/td><td>5.5<\/td><\/tr><tr><td>2026\u5e743\u6708<\/td><td>\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41668433\/\">Validated nationwide scoring system for hepatocellular carcinoma risk in metabolic dysfunction-associated steatotic liver disease<\/a><\/td><td>CAMD\u5206\u6578\u662f\u4e00\u7a2e\u6613\u65bc\u8a08\u7b97\u7684\u5de5\u5177\uff0c\u53ef\u7528\u65bc\u4fc3\u9032\u809d\u7d30\u80de\u764c\u5728\u4ee3\u8b1d\u76f8\u95dc\u8102\u80aa\u6027\u809d\u75c5\uff08MASLD\uff09\u60a3\u8005\u4e2d\u7684\u5927\u898f\u6a21\u76e3\u6e2c\u3002<\/td><td>Liver International<\/td><td>5.2<\/td><\/tr><tr><td>2026\u5e742\u670825\u65e5<\/td><td>\u5433\u8389\u73b2\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41742062\/\">Comparative analysis of renal dysfunction, immune remodeling, and gut microbiota profiles in dietary models of metabolic liver disease<\/a><\/td><td>\u7814\u7a76\u986f\u793aHFD\u8207CDAHFD\u7686\u6703\u5c0e\u81f4\u8102\u80aa\u809d\u8207\u5168\u8eab\u4ee3\u8b1d\u7570\u5e38\uff0c\u4f46CDAHFD\u5f15\u767c\u66f4\u56b4\u91cd\u7684\u809d\u81df\u767c\u708e\u3001\u81a0\u539f\u6c89\u7a4d\u53ca\u814e\u529f\u80fd\u640d\u50b7\uff0c\u800cHFD\u5247\u5448\u73fe\u8f03\u7de9\u6162\u7684\u9ad8\u8840\u7cd6\u3001\u8840\u8102\u7570\u5e38\u8207\u814e\u5c0f\u7403\u80a5\u5927\u3002\u5728\u514d\u75ab\u7d30\u80de\u7d44\u6210\u4e0a\uff0cHFD\u504f\u5411\u5de8\u566c\u7d30\u80de\u4e3b\u5c0e\uff0c\u800cCDAHFD\u5247\u589e\u52a0\u767c\u708e\u6027\u55ae\u6838\u7403\u3001\u6a39\u7a81\u7d30\u80de\u8207T\u7d30\u80de\uff0c\u986f\u793a\u4e0d\u540c\u98f2\u98df\u5c0d\u814e\u81df\u514d\u75ab\u53cd\u61c9\u5177\u6709\u7279\u7570\u6027\u5f71\u97ff\u3002<br>\u8178\u9053\u83cc\u76f8\u65b9\u9762\uff0cHFD\u8207choline-deficient, amino acid-defined high-fat diet\u5448\u73fe\u4e0d\u540c\u83cc\u7fa4\u7279\u5fb5\uff0c\u4e14CDAHFD\u4f34\u96a8\u83cc\u76f8\u591a\u6a23\u6027\u986f\u8457\u4e0b\u964d\uff0c\u986f\u793a\u5176\u5c0d\u8178\u9053\u5fae\u751f\u7269\u751f\u614b\u885d\u64ca\u8f03\u5927\u3002<\/td><td>BMC Nephrology<\/td><td>2.4<\/td><\/tr><tr><td>2026\u5e742\u67084\u65e5<\/td><td>\u9673\u6021\u5982\u4e3b\u4efb\u8207\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41634410\/#full-view-affiliation-1\">Akkermansia Muciniphila Ameliorates Imiquimod-Induced Skin Thickening, Colitis, and Gut Microbiota Alterations: A Metagenome Association Study<\/a><\/td><td>\u7814\u7a76\u767c\u73fe\uff0c\u4e7e\u766c\u8207\u4e7e\u766c\u6027\u95dc\u7bc0\u708e\u60a3\u8005\u8178\u9053\u4e2dAkkermansia muciniphila\uff08Akk\uff09\u542b\u91cf\u4e0b\u964d\uff0c\u800c\u88dc\u5145\u5df4\u6c0f\u6ec5\u6d3bAkk\uff08pAkk\uff09\u5728IMQ\u8a98\u5c0e\u5c0f\u9f20\u6a21\u578b\u4e2d\u53ef\u6539\u5584\u76ae\u819a\u589e\u539a\u3001\u9ad4\u91cd\u4e0b\u964d\u3001\u813e\u81df\u816b\u5927\u53ca\u767c\u708e\u53cd\u61c9\uff08\u5982TNF-\u03b1\u8207IL-17A\uff09\u3002pAkk\u540c\u6642\u53ef\u7de9\u89e3DSS\u8a98\u5c0e\u4e4b\u8178\u708e\uff0c\u4e26\u63d0\u5347\u8178\u9053\u83cc\u76f8\u591a\u6a23\u6027\uff0c\u6539\u8b8a\u83cc\u7fa4\u7d44\u6210\uff0c\u4e26\u8207GABA\u4ee3\u8b1d\u3001\u81bd\u9e7c\u80fd\u7a81\u89f8\u53caMAPK\u7b49\u8def\u5f91\u76f8\u95dc\u3002\u6574\u9ad4\u800c\u8a00\uff0cpAkk\u53ef\u80fd\u900f\u904e\u8abf\u63a7\u8178\u9053\u83cc\u76f8\u8207\u4ee3\u8b1d\u9014\u5f91\u3001\u964d\u4f4e\u767c\u708e\u53cd\u61c9\uff0c\u9032\u800c\u6539\u5584\u76ae\u819a\u8207\u8178\u9053\u767c\u708e\u72c0\u614b\u3002<\/td><td>Inflammation<\/td><td>5<\/td><\/tr><tr><td>2026\u5e742\u67083\u65e5<\/td><td>\u9ad8\u6b63\u5f65\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41498542\/\">A combined genetic and phenotypic marker approach enables precise detection of hypervirulent Klebsiella pneumoniae and reveals associated traits of capsule overproduction and tellurite resistance<\/a><\/td><td>\u672c\u7814\u7a76\u6574\u5408\u57fa\u56e0\u8207\u8868\u578b\u5206\u6790\uff0c\u6bd4\u8f03\u78b3\u9752\u9ef4\u70ef\u6297\u85e5\u6027\u8207\u809d\u81bf\u760d\u76f8\u95dc\u4e4bKlebsiella pneumoniae\u83cc\u682a\uff0c\u767c\u73fe\u4e94\u500b\u6bd2\u529b\u57fa\u56e0\uff08peg-344\u3001iroB\u3001iucA\u3001prmpA\u3001prmpA2\uff09\u7d50\u5408string test\u53ef\u6709\u6548\u9451\u5b9a\u9ad8\u6bd2\u529b\u83cc\u682a\uff08hvKp\uff09\u3002\u7d50\u679c\u986f\u793a\uff0c\u5e36\u6709\u4e94\u500b\u57fa\u56e0\u7684\u83cc\u682a\u7121\u8ad6string test\u662f\u5426\u967d\u6027\uff0c\u7686\u5177\u6709\u8f03\u9ad8\u6bd2\u529b\u8207\u83a2\u819c\u7522\u91cf\uff0c\u5176\u4e2dLAKp\u7d44\u5225\u7684\u81f4\u6b7b\u6027\u8207\u83a2\u819c\u751f\u6210\u6700\u70ba\u986f\u8457\uff0c\u800c\u7f3a\u4e4f\u9019\u4e9b\u57fa\u56e0\u7684CRcKp\u5247\u8868\u73fe\u6700\u4f4e\u6bd2\u529b\u3002\u9577\u671f\u76e3\u6e2c\u4ea6\u767c\u73fe\u8840\u6db2\u5206\u96e2\u682a\u4e2d\u651c\u5e36\u4e94\u9805\u6bd2\u529b\u6a19\u8a18\u7684\u6bd4\u4f8b\u9ad8\u65bc\u5c3f\u6db2\u5206\u96e2\u682a\uff0c\u986f\u793a\u9019\u4e9b\u751f\u7269\u6a19\u8a18\u6709\u52a9\u65bc\u63d0\u5347hvKp\u7684\u81e8\u5e8a\u6aa2\u6e2c\u8207\u98a8\u96aa\u8a55\u4f30\u3002<\/td><td>Microbiol Spectr<\/td><td>3.8<\/td><\/tr><tr><td>2026\u5e742\u6708<\/td><td>\u9ad8\u6b63\u5f65\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s13099-026-00817-5\">Genotypes, antibiotic resistance, and virulence diversity among Klebsiella pneumoniae species complex isolates in Taiwan<\/a><\/td><td>\u5728\u53f0\u7063\uff0cKlebsiella pneumoniae\u3001Klebsiella quasipneumoniae\u8207Klebsiella variicola\u5c55\u73fe\u51fa\u4e0d\u540c\u7684\u57fa\u56e0\u578b\u8207\u8868\u578b\u7279\u5fb5\u3002\u5176\u4e2dK. quasipneumoniae\u8207K. variicola\u5728\u5e7c\u87f2\u611f\u67d3\u6a21\u578b\u4e2d\u9020\u6210\u8f03\u9ad8\u6b7b\u4ea1\u7387\uff0c\u986f\u793a\u5176\u6f5b\u5728\u81f4\u75c5\u529b\u4e0d\u5bb9\u5ffd\u8996\u3002\u56e0\u6b64\uff0c\u6301\u7e8c\u76e3\u6e2c\u9019\u4e9b\u83cc\u7a2e\u7684\u50b3\u64ad\u8207\u6d41\u884c\u60c5\u5f62\u5177\u6709\u91cd\u8981\u610f\u7fa9\u3002<\/td><td>Gut Pathogens<\/td><td>4<\/td><\/tr><tr><td>2026\u5e742\u6708<\/td><td>\u5433\u8389\u73b2\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/academic.oup.com\/rheumatology\/article-abstract\/65\/4\/keag133\/8540464\">Cumulative defined daily doses Enables Objective Assessment of Treatment Intensity and Outcome Prediction in IgG4-RD and Its subtypes<\/a><\/td><td>\u4e0d\u540c\u7684\u589e\u751f\u578b\u8207\u7e96\u7dad\u5316\u578b\u8868\u73fe\u5177\u6709\u5dee\u7570\u6027\u7684\u98a8\u96aa\u8207\u6cbb\u7642\u53cd\u61c9\u3002\u900f\u904e\u5b9a\u91cf\u8a55\u4f30cDDD\uff08\u7d2f\u7a4d\u5b9a\u7fa9\u65e5\u5291\u91cf\uff09\u53ef\u5ba2\u89c0\u53cd\u6620\u6cbb\u7642\u5f37\u5ea6\u4e26\u9810\u6e2c\u81e8\u5e8a\u7d50\u679c\u3002\u6b64\u65b9\u6cd5\u6709\u52a9\u65bc\u63a8\u52d5IgG4\u76f8\u95dc\u75be\u75c5\u7684\u5206\u671f\u5c0e\u5411\u8207\u7cbe\u6e96\u6cbb\u7642\u7b56\u7565\u3002<\/td><td>Rheumatology<\/td><td>4.4<\/td><\/tr><tr><td>2026\u5e741\u670820\u65e5<\/td><td>\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/www.nature.com\/articles\/s41467-026-68368-6\">Unbiased clustering of acute-on-chronic liver failure patients using machine learning in a real-world ICU cohort.<\/a><\/td><td>\u672c\u7814\u7a76\u91dd\u5c0d 1,256 \u540d\u6025\u6027\u6162\u6027\u809d\u8870\u7aed\uff08ACLF\uff09\u60a3\u8005\u9032\u884c\u7121\u76e3\u7763\u5206\u7fa4\u5206\u6790\uff0c\u6210\u529f\u8fa8\u8b58\u51fa\u5169\u500b\u81e8\u5e8a\u7279\u5fb5\u8207\u9810\u5f8c\u986f\u8457\u4e0d\u540c\u7684\u65cf\u7fa4\uff0c\u4e14 30 \u5929\u6b7b\u4ea1\u7387\u5dee\u7570\u660e\u986f\uff0870.35% vs 26.06%\uff09\u3002\u6700\u4f73\u6a21\u578b\u63a1\u7528\u975e\u8ca0\u77e9\u9663\u5206\u89e3\uff08Lee\u2019s algorithm\uff09\uff0c\u4e26\u4ee5 PAM \u5206\u7fa4\u65b9\u6cd5\u6c7a\u5b9a\u7fa4\u6578\uff0c\u986f\u793a\u9178\u9e7c\u5e73\u8861\u76f8\u95dc\u6307\u6a19\uff08\u5982 bicarbonate\u3001pH\u3001lactate \u7b49\uff09\u70ba\u95dc\u9375\u5206\u7fa4\u56e0\u5b50\u3002\u5916\u90e8\u9a57\u8b49\uff08\u5305\u542b\u5931\u4ee3\u511f\u6027\u809d\u786c\u5316\u8207\u6b50\u6d32\u968a\u5217\uff09\u7d50\u679c\u4e00\u81f4\uff0c\u652f\u6301\u6b64\u5206\u7fa4\u65b9\u6cd5\u7684\u7a69\u5b9a\u6027\uff0c\u4e26\u5f37\u8abf\u4ee3\u8b1d\u8abf\u63a7\u5728 ACLF \u9810\u5f8c\u4e2d\u7684\u91cd\u8981\u89d2\u8272\u3002<\/td><td>Nature Communication<\/td><td>15.7<\/td><\/tr><tr><td>2026\u5e741\u670819\u65e5<\/td><td>\u9ad8\u6b63\u5f65\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1876034125003673\">Emergence of conjugative metallo-\u03b2-lactamase-encoding plasmids in the Klebsiella pneumoniae species complex: First identification of IMP-8-MCR-9.1 in K. quasipneumoniae and VIM-1 in K. variicola in Taiwan<\/a><\/td><td>\u5728 CRKpSC \u5206\u96e2\u682a\u4e2d\uff0cblaKPC \u6700\u5e38\u898b\uff0820.1%\uff09\uff0c\u5176\u6b21\u70ba blaOXA-48\uff083.4%\uff09\uff0c\u800c blaIMP\u3001blaNDM\u3001blaVIM \u5747\u76f8\u7576\u7f55\u898b\uff08\u22641%\uff09\uff0c\u4e14\u50c5\u6975\u5c11\u6578\u83cc\u682a\u540c\u6642\u5e36\u6709\u591a\u7a2e\u57fa\u56e0\u3002\u50c5\u6709\u5c11\u6578 Kq \u8207 Kv \u83cc\u682a\u651c\u5e36\u91d1\u5c6c\u03b2-\u5167\u91af\u80fa\u9176\u57fa\u56e0\uff0c\u5176\u4e2d pNCKUH114\u20131 \u8cea\u9ad4\u5e36\u6709 blaIMP-8 \u8207 mcr-9.1\uff0cpNTUH73\u20131 \u5247\u5e36\u6709 blaVIM-1\uff0c\u4e14\u8207\u8cc7\u6599\u5eab\u4e2d\u5df2\u77e5\u8cea\u9ad4\u76f8\u4f3c\u5ea6\u6709\u9650\u3002\u9019\u5169\u7a2e\u8cea\u9ad4\u50c5\u80fd\u8f49\u79fb\u81f3 E. coli EC359\uff0c\u4e14\u5728\u5be6\u9a57\u689d\u4ef6\u4e0b\u4e26\u672a\u589e\u52a0\u5176\u5c0d\u5e7c\u87f2\u7684\u81f4\u75c5\u529b\u3002<\/td><td>Journal of Infection and Public Health<\/td><td>4<\/td><\/tr><tr><td>2026\u5e741\u670812\u65e5<\/td><td>\u694a\u6bc5\u8f1d\u8207\u5433\u4fca\u7a4e\u8001\u5e2b\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41743689\/\">Dynamic FIB-4 score changes and HCC risk in patients with MASLD and elevated liver enzymes: a nationwide cohort study.<\/a><\/td><td>\u96a8\u6642\u9593\u8b8a\u5316\u7684 FIB-4 \u5206\u6578\u8f03\u55ae\u6b21\u6e2c\u91cf\u5177\u6709\u66f4\u4f73\u7684\u809d\u764c\uff08HCC\uff09\u9810\u6e2c\u80fd\u529b\u3002\u6301\u7e8c\u9ad8 FIB-4\uff08high-to-high\uff09\u65cf\u7fa4\u7684 HCC \u98a8\u96aa\u6700\u9ad8\uff0c\u7d04\u70ba\u7a69\u5b9a\u4f4e\u503c\uff08low-to-low\uff09\u7684 14 \u500d\uff0c\u800c\u5206\u6578\u6539\u5584\u8005\uff08high-to-low\u3001high-to-indeterminate\uff09\u98a8\u96aa\u5247\u660e\u986f\u964d\u4f4e\u3002FIB-4 \u60e1\u5316\uff08low-to-indeterminate\u3001low-to-high\uff09\u8207\u9010\u6b65\u4e0a\u5347\u7684 HCC \u98a8\u96aa\u76f8\u95dc\uff0c\u4f46\u76f8\u8f03\u65bc\u6301\u7e8c\u9ad8\u503c\u65cf\u7fa4\uff0c\u5206\u6578\u6539\u5584\u8005\u4ecd\u5448\u73fe\u986f\u8457\u8f03\u4f4e\u7684\u98a8\u96aa\u3002<\/td><td>Liver Cancer<\/td><td>9.1<\/td><\/tr><tr><td>2025\u5e7412\u6708(accepted)<\/td><td>\u5f35\u5a77\u5a77\u526f\u6559\u6388\u7b49<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41371582\/#full-view-affiliation-1\">Sodium nitroprusside improves ischemia-induced neovascularization via the HO-1\/NOX and AKT\/eNOS signaling pathways in chronic kidney disease.<\/a><\/td><td>\u7814\u7a76\u986f\u793a\uff0c\u6162\u6027\u814e\u81df\u75c5\u4e2d\u5e38\u898b\u7684\u5c3f\u6bd2\u7d20\uff08\u5982 ADMA\u3001IS\uff09\u6703\u9020\u6210\u6c27\u5316\u58d3\u529b\u4e0a\u5347\u8207\u4e00\u6c27\u5316\u6c2e\u751f\u6210\u4e0b\u964d\uff0c\u9032\u800c\u5c0e\u81f4\u8840\u7ba1\u5167\u76ae\u640d\u50b7\u8207\u5468\u908a\u52d5\u8108\u75be\u75c5\u60e1\u5316\u3002<br>\u5728 CKD \u5c0f\u9f20\u7684\u7f3a\u8840\u6a21\u578b\u4e2d\uff0c\u785d\u666e\u9209\uff08SNP\uff09\u80fd\u63d0\u5347\u4fc3\u8840\u7ba1\u65b0\u751f\u56e0\u5b50\u3001\u6539\u5584\u8840\u6d41\u6062\u5fa9\u3001\u589e\u52a0\u6bdb\u7d30\u8840\u7ba1\u5bc6\u5ea6\uff0c\u4e26\u8abf\u7bc0\u7f3a\u8840\u7d44\u7e54\u7684\u708e\u75c7\u8207\u8840\u7ba1\u65b0\u751f\u76f8\u95dc\u86cb\u767d\u3002<br>SNP \u5728\u9ad4\u5916\u4ea6\u80fd\u6539\u5584\u53d7 ADMA \u6216 IS \u523a\u6fc0\u7684\u5167\u76ae\u7d30\u80de\u529f\u80fd\uff0c\u900f\u904e HO-1\/NOX \u8207 AKT\/eNOS \u8def\u5f91\u964d\u4f4e\u6c27\u5316\u58d3\u529b\u4e26\u4fc3\u9032\u8840\u7ba1\u65b0\u751f\uff0c\u986f\u793a\u5176\u53ef\u80fd\u6210\u70ba CKD \u4f34\u96a8\u8840\u7ba1\u4f75\u767c\u75c7\u7684\u6f5b\u5728\u6cbb\u7642\u7b56\u7565\u3002<\/td><td>Life Sciences<\/td><td>5.1<\/td><\/tr><tr><td>2025\u5e7411\u6708(accepted)<\/td><td>\u5433\u4fca\u7a4e\u6559\u6388\u8207\u90ed\u6b63\u6d69\u540c\u5b78\u7b49\u4eba<\/td><td><a href=\"https:\/\/www.nature.com\/articles\/s41467-025-67326-y\">Increased risk of antimicrobial resistance in patients with cirrhosis and hepatic encephalopathy using rifaximin<\/a><\/td><td>\u672c\u7bc7\u7814\u7a76\u5728\u8a55\u4f30Rifaximin\u5728\u809d\u786c\u5316\u5408\u4f75\u809d\u6027\u8166\u75c5\u60a3\u8005\u4e2d\u7684\u4f7f\u7528\u662f\u5426\u589e\u52a0\u6297\u751f\u7d20\u6297\u85e5\u6027\u98a8\u96aa\uff0c\u7814\u7a76\u7d50\u679c\u767c\u73fe\uff0cRifaximin\u8207\u6557\u8840\u75c7\u3001\u81ea\u767c\u6027\u7d30\u83cc\u6027\u8179\u819c\u708e\u53ca\u9700\u4f7f\u7528\u6700\u5f8c\u7dda\u6297\u751f\u7d20\u7684\u98a8\u96aa\u589e\u52a0\u76f8\u95dc\u3002<\/td><td>Nature Communication<\/td><td>15.7<\/td><\/tr><tr><td>2025\u5e7410\u670817\u65e5<\/td><td>\u5433\u4fca\u7a4e\u6559\u6388\u8207\u6797\u9a30\u7acb\u540c\u5b78\u7b49\u4eba<\/td><td><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41105233\/\">Psoriatic arthritis risk in psoriasis patients receiving anti-IL-23 vs anti-IL-17: comparison of drug classes and individual agents<\/a><\/td><td>\u672c\u7814\u7a76\u6bd4\u8f03\u4e7e\u766c\u60a3\u8005\u4f7f\u7528 IL-23 \u6291\u5236\u5291\u8207 IL-17 \u6291\u5236\u5291\u5f8c\u767c\u5c55\u4e7e\u766c\u6027\u95dc\u7bc0\u708e\u7684\u98a8\u96aa\u5dee\u7570\u3002\u5728 1:1 \u914d\u5c0d\u5f8c\u7684 5,490 \u540d\u60a3\u8005\u4e2d\uff0cIL-23 \u6291\u5236\u5291\u4f7f\u7528\u8005\u7684 5 \u5e74\u4e7e\u766c\u6027\u95dc\u7bc0\u708e\u7d2f\u7a4d\u767c\u751f\u7387\u660e\u986f\u8f03\u4f4e\uff0811.68% vs 19.94%\uff09\uff0c\u98a8\u96aa\u6bd4\u70ba 0.475\u3002\u591a\u9805\u5b50\u65cf\u7fa4\u8207\u500b\u5225\u85e5\u7269\u6bd4\u8f03\u5747\u5448\u73fe\u76f8\u540c\u8da8\u52e2\uff0c\u986f\u793a IL-23 \u6291\u5236\u5291\u76f8\u8f03\u65bc IL-17 \u6291\u5236\u5291\u66f4\u80fd\u964d\u4f4e\u4e7e\u766c\u60a3\u8005\u5f8c\u7e8c\u767c\u5c55\u95dc\u7bc0\u708e\u7684\u98a8\u96aa\u3002<\/td><td>Rheumatology<\/td><td>4.4<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-995f960e wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow 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