碩博士生

吳俊穎老師團隊


陳彥伶
博士生

學歷：
國立陽明交通大學 博士生

研究領域：

研究發表：


郭正浩
博士生

學歷：
國立陽明交通大學 博士生
國立陽明交通大學 醫學系

研究領域：
宿主-微菌交互作用
人類微菌研究
臨床大數據研究

研究發表：
Kuo CH, … Wu CY. Direct effects of alcohol on gut-epithelial barrier: Unraveling the disruption of physical and chemical barrier of the gut-epithelial barrier that compromises the host-microbiota interface upon alcohol exposure. J Gastroenterol Hepatol. 2024;39(7):1247-1255.

林騰立
博士生

學歷：

研究領域：

研究發表：


薛竹珺
碩士生

學歷：
國立陽明交通大學 生物醫學資訊所 碩士生
國立成功大學 學士

研究領域：
健保資料庫分析
健康大數據分析
資料分析與資料補值
機器學習

研究發表：
Hsueh CC, Wu CY, … FIB-4 associated with risk of hepatocellular carcinoma in patients with alcohol-related liver diseases. Presented at: 2025 Digestive Disease Week® (DDW); 2025 May 3-6; San Diego, CA, USA.

嚴紹武
碩士生

學歷：
國立陽明交通大學 生物醫學資訊所 碩士生
台北醫學大學 生物醫學工程 學士

研究領域：
醫學數據分析與應用
醫學影像處理
機器學習與深度學習
多模態數據分析

研究發表：


陳霈珊
碩士生

學歷：
國立陽明交通大學 生物醫學資訊所 碩士生

研究領域：

研究發表：


黃鈺琇
碩士生

學歷：
國立陽明交通大學 生物醫學資訊所 碩士生

研究領域：

研究發表：

高正彥老師團隊


Jazon Harl Hidrosollo
博士生

學歷：
Ms., Department of Medical Technology, University of San Agustin, Philippines

研究領域：
The mechanism of compound 4e against S. lugdunensis

Investigating the mechanism of compound 4e derivatives against S. lugdunensis and the mechanism of drug resistance

Association between genotypes and virulence of SL (side project)

The interaction between urinary stones and microbiota (side project)

研究發表：

張晏蓁
博士生

學歷：
Bs., Department of Biotechnology and Laboratory Science in medicine, National Yang-Ming University, Taiwan

Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan

研究領域：
Investigating the evolutionary mechanisms of strains in patients with recurrent urinary tract infections

Exploring the characteristics of bacteria causing systemic infections 

Characteristics and diagnosis of carbapenemase-producing bacteria (side project)

Investigation of the correlation between microbiota and diseases (side project)

研究發表：

郭沛昀
博士生

學歷：
Bs., Department of Biotechnology and Laboratory Science in medicine, Chang-Gung University, Taiwan

Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan

研究領域：
Investigating the roles and interactions of Jhp0417 and Jhp0106 
Exploring the regulatory mechanisms of CsrA 
Investigating the influence of strain-specific regulation of CsrA variants on bacterial virulence
Developing novel probiotics for pets (side project)

研究發表：

Tran Thi Dieu Thuy
博士生

學歷：
Bs., Department of biotechnology, Ton Duc Thang University, Vietnam

Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan

研究領域：
Development and mechanism exploration of traditional probiotic products against pathogenic bacteria

Development of next-generation probiotics for anti-aging effects 

Investigation of the correlation between microbiota and male reproductive tract diseases  
(side project)

研究發表：

Tran Thi Thuy Duong
博士生

學歷：
Bs., Department of biotechnology, Ton Duc Thang University, Vietnam

Ms., Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taiwan

研究領域：
Investigating the characteristics of CRhvKP and developing a screening platform

Exploring the evolution and characteristics of CRhvKP, hvKP, and LAhvKP plasmids

Developing bacteriophages to inhibit CRhvKP

Investigating the role of novel virulence factors in the pathogenesis of CRKP 
Studying the evolution of hvKP within the host

Developing antibacterial compounds and analyzing their mechanisms (side project)

研究發表：

Carl Jay Ballena Bregente
博士生

學歷：
Ms., Blizard Institute, London, United Kingdom

研究領域：
Investigating the characteristics of carbapenem-resistant (CAZ-AVI/cefiderocol/colistin-resistant) Pseudomonas aeruginosa

Exploring the characteristics of hypervirulent and carbapenem-resistant Pseudomonas aeruginosa (HvCRPA)

Development of bacteriophages to combat HvCRPA
Development of bacteriophages to combat carbapenem-resistant Enterobacter cloacae (side project)

Investigation of the correlation between microbiota and male reproductive tract diseases (side project)

研究發表：

曾琣淇
博士生

學歷：
Bs., Universiti Tunku Abdul Rahman, Malaysia

研究領域：
Analysis of the characteristics and mechanisms of hypervirulent extensively drug-resistant Acinetobacter baumannii

Analysis of novel mechanisms of carbapenem resistance in Acinetobacter baumannii

Development of bacteriophages to combat hypervirulent XDR Acinetobacter baumannii

Analysis of the impact and mechanisms of induced resistance in Acinetobacter baumannii on pathogenicity

Development of probiotics with the potential to inhibit rUTI (side project)

研究發表：

杜佩純
博士生

學歷：
Bs., Department of Food Science and Biotechnology, Chung Hsing University, Taiwan

研究領域：
Development and mechanistic study of Next-Generation Probiotics against metabolic syndrome

研究發表：

鄭雅裕
博士生

學歷：
Bs., Department of Life Science, National Tsing Hua University, Taiwan

研究領域：
The bacterial interactions in polymicrobial infections and their impact on bacterial pathogenesis

研究發表：

Nevia Longjam
博士生

學歷：
B.Sc Biotechnology: Chandigarh University, India

M.Sc Biotechnology : Bharathiar University India

研究領域：
Investigation the role of Jhp0550 and carbon storage regulator system (Csr) in J99 Helicobacter pylori pathogenesis

Characterization of the virulence phenotypes and its association with genetic profiles in Staphylococcus lugdunensis clinical isolates

研究發表：

Tong Dang Khoa
碩士生

學歷：
Bs., Ho Chi Minh City International University, Vietnam

研究領域：
Investigating the characteristics of siderophore-carbapenemase carrying plasmids and their impact on bacterial pathogenesis

研究發表：

Bui Thi Linh
碩士生

學歷：
Bs., Department of biotechnology and food technology, Thai Nguyen University of Agriculture and Forestry, Vietnam

研究領域：
Characterizing probiotics with antimicrobial and bile salt hydrolase (BSH) activity for product development

研究發表：

Alonso Enrique Africa
碩士生

學歷：
Bs., College of Science of the University of Santo Tomas, Philippines

研究領域：
Development and mechanism studies of antimicrobial active compounds
 
Development of compounds that inhibit PASTA kinase activity (side project)

研究發表：

張紫林
碩士生

學歷：
Bs., Department of Molecular Biology and Human Genetics, Tzu Chi University, Taiwan

研究領域：
Characterization of novel virulence factors in H. pylori pathogenesis

研究發表：

謝佳羽
碩士生

學歷：
Bs., Medical Laboratory Science and Biotechnology, China Medical University, Taiwan

研究領域：
Antibiotic resistance

研究發表：

Laishram Yashmine Devi
碩士生

學歷：
Bs., Department of Biology, Indian Institute of Science Education and Research (IISER), India

研究領域：
Next generation probiotics

研究發表：

Yi-Ru Boey
碩士生

學歷：
Bs., Department of Life Science, National Cheng Kung University, Taiwan

研究領域：
Recurrent infection

研究發表：

吳容瑄
碩士生

學歷：
Bs., Department of Food Science and Biotechnology, Chung Hsing University, Taiwan

研究領域：
Development of probiotics

研究發表：

Nguyen Van Tat Thanh
碩士生

學歷：
Bs.,  Pharmacological Medical and Agronomical Biotechnology at University of science and technology of Hanoi

研究領域：
Development of probiotics

研究發表：

吳莉玲老師團隊


高義筑(Yi-Chu Kao)
博士生

學歷：
M.D., Doctor of Medicine, Taipei Medical University, Taipei, Taiwan

研究領域：
Pathophysiology of Liver, Ischemia and Reperfusion Injury of Liver,  Kupffer Cells and Innate Lymphoid Cells of Liver

研究發表：
1. Hidenobu Kojima, Thomas A Morinelli, Yue Wang, Jackson L Chin, Aaron S Meyer, Yi-Chu Kao, Kentaro Kadono, Siyuan Yao, Taylor Torgerson, Kenneth J Dery, Adil Bhat, Elaine F Reed, Fady M Kaldas, Dirk J van der Windt, Douglas G Farmer, Jerzy W Kupiec-Weglinski, Yuan Zhai (2025, May). Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway. American Journal of Transplantation, 25(5):969-984.

2. Chun-Han Lin, Ivy Yenwen Chau, Hao-Jan Lei, Shu-Cheng Chou, Yi-Chu Kao, Ching-Chu Chiang, Chan-Wei Tseng, Cheng-Yuan Hsia, Gar-Yang Chau (2025, Apr). Safety and Efficacy of the Hand-Assisted Laparoscopic Approach for Repeat Hepatectomy: A Propensity Score Matching Analysis. World Journal of Surgery, 49(4):1090-1100.

3. Chen CE, Kao YC, Ku SH (2023, Oct). Fleur-de-lis Miniabdominoplasty Access in Radical Resection of a Large Abdominal Wall Desmoid Tumor. Plastic and Reconstructive Surgery – Global Open, 26;11(10).

4. Lai HF, Chau IY, Lei HJ, Chou SC, Hsia CY, Kao YC, Chau GY (2022, Jan). Postoperative fever after liver resection: Incidence, risk factors, and characteristics associated with febrile infectious complication. PLOS ONE, 13;17(1):e0262113. 本人為通訊作者.

5. Lei HJ, Wang SY, Chau IY, Li AF, Chau YP, Hsia CY, Chou SC, Kao YC, Chau GY (2021, Jun). Hepatoma upregulated protein and Ki-67 expression in resectable hepatocellular carcinoma. Journal of the Chinese Medical Association, 1;84(6):623-632.

6. Kao YC, Fang WL, Wang RF, Li AF, Yang MH, Wu CW, Shyr YM, Huang KH. (2019, Mar). Clinicopathological differences in signet ring cell adenocarcinoma between early and advanced gastric cancer. Gastric Cancer. Gastric Cancer, 22:255-263. 本人為第一作者.

7. 高義筑, 周書正, 雷浩然（2020年05月）。淺談靛氰綠ICG螢光顯影在微創肝臟手術的應用。，Pp. 255-259。本人為第一作者、通訊作者。

李宥蓁（You-jhen Li ）
博士生		學歷：
Institute of Biomedical Sciences, National Tsing Hua University, Hsinchu

研究領域：
Gut microbiota, Obesity, Gut-Liver axis

研究發表：
1. Po-Chun Huang, Jui-Chen Tsai, Kuan-Chen Chen, Ju-Yi Cheng, You-jhen Li, Ai-Leng Feng, Wei-Hao Peng and Li-Ling Wu. CRISPR/Cas9-Mediated TLR4 Knockout Protects Male Mice from HFD-Induced Gut–Liver–Kidney Axis Dysfunction via Microbiota–Immune Modulation. APCN & TSN 2025 . (Poster presentation) .

范沛涵 (Pei-Han Fan)
碩士生		學歷：
B.Sc Department of Microbiology, Immunology, and Biopharmaceuticals, National Chiayi University

研究領域：
Gut microbiota, IBD, Gut barrier

研究發表：
1. Jui-Chen Tsai, Kai-Hung Tsai, Ho-Yu Kuo, Pei-Han Fan, Hsiao-Li Chuang and Li-Ling Wu*. (2025) Protective Effects of Clostridium butyricum on Gut Barrier Integrity and Intrahepatic Immune Response Against LPS-Induced Liver Injury. Digestive Disease Week® (DDW2025), San Diego, CA, U.S.A., 2025. (Poster presentation) (論文傑出海報獎)

2. Kai-Hung Tsai, Jui-Chen Tsai, Ho-Yu Kuo, Pei-Han Fan, Wei-Hao Peng and Li-Ling Wu*（2025）Integrated Multi-Omics Approach Reveals Nfil3-Dependent Effects of Sleep Deprivation on Gut Barrier and Immune Surveillance in Hepatocellular Carcinoma. Digestive Disease Week® (DDW2025), San Diego, CA, U.S.A., 2025. (Oral presentation)

3. Kai-Hung Tsai, Jui-Chen Tsai, Ho-Yu Kuo, Pei-Han Fan, Wei-Hao Peng and Li-Ling Wu* （2025）Multi-Omics Profiling Highlights Nfil3-Driven Gut Barrier and Immune Dysregulation in HCC under Sleep Deprivation. APASL. 2025-3-26~30. Beijing, China.  (e-Poster presentation).

4. Jui-Chen Tsai, Kai-Hung Tsai, Ho-Yu Kuo, Pei-Han Fan, Hsiao-Li Chuang and Li-Ling Wu*. (2025) Clostridium butyricum-Derived Metabolites Enhance Gut-Liver Axis Integrity to Mitigate LPS-Induced Hepatic Inflammation. APASL. 2025-3-26~30. Beijing, China. (Poster presentation).

5. Chi-Chen Cheng, Hsiao-Ping Chen, Ho-Yu Kuo, Pei- Han Fan, Jie-Lun Ku, Cheng-Hao Kuo, Chun-Ying Wu, Li-Ling Wu* (2024). CRISPR/Cas9-Mediated TLR4 Knockout Attenuates Hepatocellular Carcinoma Progression in Mice by Modulating the Kinetics of Myeloid-Derived Suppressor Cell Subsets. Taiwan Digestive Disease Week® (TDDW2024), Oct 5-6, 2024, Kaohsiun, Taiwan. (Poster presentation)

6. Chi-Chen Cheng, Hsiao-Ping Chen, Ho-Yu Kuo, Pei- Han Fan, Jie-Lun Ku, Cheng-Hao Kuo, Chun-Ying Wu, Li-Ling Wu*. CRISPR/Cas9-Mediated TLR4 Knockout Attenuates Hepatocellular Carcinoma Progression in Mice by Modulating the Kinetics of Myeloid-Derived Suppressor Cell Subsets. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Oral presentation)

7. Ho-Yu Kuo, Pei-Han Fan, Hsiao-Ping Chen, Chen-Hao Kuo, Kai-Hung Tsai, Jui-Chen Tsai, and Li-Ling Wu. Taurine-Mediated modulation of gut microbiota and inflammatory intrahepatic immune response attenuates fibrosis in CDAHFD-induced metabolic-associated steatohepatitis. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation) (論文傑出海報獎)

8. Cheng-Hao Kuo, Hsiao-Ping Chen, Ho-Yu Kuo, Pei-Han Fan, Li-Ling Wu*, and Chun-Ying Wu*. METABOLIC SWITCHING, GUT INTEGRITY AND HOST-MICROBIOTA INTERACTION IN ALCOHOL-INDUCED INTESTINAL INJURY. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation)

9. Chia-Sheng Chu, Hsiao-Ping Chen, Pin-Hung Lin, Chi-Chen Cheng, Ho-Yu Kuo, Pei-Han Fan, Chun-Ying Wu and Li-Ling Wu*. ROLE OF IL-1R1 AND MYELOID-DERIVED SUPPRESSOR CELLS IN HEPATOCELLULAR CARCINOMA PROGRESSION AND IMMUNOTHERAPY. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation)

蔡鎧鴻 (Kai-Hung Tsai)
碩士生		學歷：
B.Sc Department of Microbiology, Immunology, and Biopharmaceuticals, National Chiayi University

研究領域：
Gut microbiota, HCC, Sleep deprivation

研究發表：
1. Kai-Hung Tsai, Jui-Chen Tsai, Ho-Yu Kuo, Pei-Han Fan, Wei-Hao Peng and Li-Ling Wu*（2025）Integrated Multi-Omics Approach Reveals Nfil3-Dependent Effects of Sleep Deprivation on Gut Barrier and Immune Surveillance in Hepatocellular Carcinoma. Digestive Disease Week® (DDW2025), San Diego, CA, U.S.A., 2025. (Oral presentation)

2. Kai-Hung Tsai, Jui-Chen Tsai, Ho-Yu Kuo, Pei-Han Fan, Wei-Hao Peng and Li-Ling Wu* （2025）Comprehensive Multi-Omics Analysis Identifies Mechanisms of Sleep Deprivation in Gut Microbiota and Immune Modulation of Hepatocellular Carcinoma in Nras/Shp53/SB100-Driven HCC mouse Models. 第39屆生物醫學聯合學術年會, 2025. 機構:國立陽明大學生理所 (Poster presentation).

3. Jui-Chen Tsai, Kai-Hung Tsai, Ho-Yu Kuo, Pei-Han Fan, Hsiao-Li Chuang and Li-Ling Wu*. (2025) Protective Effects of Clostridium butyricum on Gut Barrier Integrity and Intrahepatic Immune Response Against LPS-Induced Liver Injury. Digestive Disease Week® (DDW2025), San Diego, CA, U.S.A., 2025. (Poster presentation) (論文傑出海報獎)

4. Ho-Yu Kuo, Pei-Han Fan, Hsiao-Ping Chen, Chen-Hao Kuo, Kai-Hung Tsai, Jui-Chen Tsai, and Li-Ling Wu. Taurine-Mediated modulation of gut microbiota and inflammatory intrahepatic immune response attenuates fibrosis in CDAHFD-induced metabolic-associated steatohepatitis. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation) (論文傑出海報獎)

蔡睿辰 (Jui-Chen Tsai)
碩士生		學歷：
B.Sc Fu Jen Catholic University Department of Nutritional Science

研究領域：
Gut microbiota, LPS, Gut Barrier function

研究發表：
1. Jui-Chen Tsai, Kai-Hung Tsai, Ho-Yu Kuo, Pei-Han Fan, Hsiao-Li Chuang and Li-Ling Wu*. (2025) Protective Effects of Clostridium butyricum on Gut Barrier Integrity and Intrahepatic Immune Response Against LPS-Induced Liver Injury. Digestive Disease Week® (DDW2025), San Diego, CA, U.S.A., 2025. (Poster presentation) (論文傑出海報獎)

2. Jui-Chen Tsai, Kai-Hung Tsai, Ho-Yu Kuo, Pei-Han Fan, Hsiao-Li Chuang and Li-Ling Wu*. (2025) Clostridium butyricum-Derived Metabolites Enhance Gut-Liver Axis Integrity to Mitigate LPS-Induced Hepatic Inflammation. APASL. 2025-3-26~30. Beijing, China. (Poster presentation).

3. Kai-Hung Tsai, Jui-Chen Tsai, Ho-Yu Kuo, Pei-Han Fan, Wei-Hao Peng and Li-Ling Wu* （2025）Multi-Omics Profiling Highlights Nfil3-Driven Gut Barrier and Immune Dysregulation in HCC under Sleep Deprivation. APASL. 2025-3-26~30. Beijing, China. (e-Poster presentation).

4. Kai-Hung Tsai, Jui-Chen Tsai, Ho-Yu Kuo, Pei-Han Fan, Wei-Hao Peng and Li-Ling Wu*（2025）Integrated Multi-Omics Approach Reveals Nfil3-Dependent Effects of Sleep Deprivation on Gut Barrier and Immune Surveillance in Hepatocellular Carcinoma. Digestive Disease Week® (DDW2025), San Diego, CA, U.S.A., 2025. (Oral presentation)

5. Ju-Yi Cheng, Jui-Chen Tsai, Po-Chun Huang, Pei-Hsuan Wu, Kai-Hung Tsai, Wei-Hao Peng*, and Li-Ling Wu*. (2025) CRISPR/Cas9-Mediated TLR4 Knockout Reveals in Modulating Gut Microbiota and Metabolic Pathways under HBV-Induced Hepatocellular Carcinoma. Digestive Disease Week® (DDW2025), San Diego, CA, U.S.A., 2025. (Poster presentation) (論文傑出海報獎)

6. Po-Chun Huang, Jui-Chen Tsai, Kuan-Chen Chen, Ju-Yi Cheng, You-jhen Li, Kai-Hung Tsai, Ai-Leng Feng, Wei-Hao Peng and Li-Ling Wu. CRISPR/Cas9-Mediated TLR4 Knockout Protects Male Mice from HFD-Induced Gut–Liver–Kidney Axis Dysfunction via Microbiota–Immune Modulation. APCN & TSN 2025 . (Poster presentation) .

7. Pei-Han Fan, Ho-Yu Kuo, Hsiao-Ping Chen, Kai-Hung Tsai, Jui-Chen Tsai, and Li-Ling Wu* BETAINE ALLEVIATES GUT BARRIER INFLAMMATION AND Ly6C MONOCYTES AND KUPFFER CELLS ORCHESTRATE LIVER IMMUNE RESPONES PREVENTS DSS INDUCED COLITIS AND ASSOCIATED LIVER INJURY. Digestive Disease Week® (DDW2024), Washington DC. U.S.A., 2024. (Poster presentation)

劉宥羽 （yo-yu Liou ）
碩士生		學歷： Institute of Ecology and Evolutionary Biology, National Taiwan University

研究領域：Gut microbiota, HBV, Gut-Liver axis

研究發表：
1. Yo-Yu Liou, Hurng-Yi Wang, Li-Ling Wu. Exploring the role of gut microbiota in HBV clearance in a transfected mouse model. NTU College of Life Sciences 113th Academic Year Science Poster Exhibition 2025. (Poster presentation) (第一名) .

蔡柏霖 (Po-Lin Tsai)
碩士生		學歷：
B.Sc. Department of Nutrition and Health Science and Department of Nursing

研究領域：
Gut microbiota, HCC, Sleep deprivation

研究發表：

方翊晟（Fang, Yi-Cheng）
碩士生		學歷：
B.Sc Bioscience technology, Chung Yuan Christian University.

研究領域：
Gut microbiota, Pathophysiology of Liver, Ischemia and Reperfusion Injury of Liver,  Kupffer Cells and Innate Lymphoid Cells of Liver

研究發表：